* Azathioprine metabolites in autoimmune hepatitis:relationship with therapeutic efficacy

Relationship between Azathioprine metabolites and therapeutic efficacy in Chinese patients with neuromyelitis optica spectrum disorders

BACKGROUND Neuromyelitis optica spectrum disorders (NMOSD) are demyelinating autoimmune diseases in the central nervous system (CNS) that are characterized by a high relapse rate and the presence of anti-aquaporin 4 antibodies (AQP4-IgG) in the serum. Azathioprine (AZA) is a first-line immunomodulatory drug that is widely used for the treatment of patients with NMOSD. However, the efficacy and ...

Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease.

BACKGROUND 6-Mercaptopurine (6-MP) and its prodrug azathioprine (AZA) have proven efficacy in the treatment of Crohn disease (CD). The immunosuppressive properties of AZA/6-MP are mediated by the intracellular metabolism of 6-MP into its active metabolites, 6-thioguanine nucleotides (6TGN) and 6methylmercaptopurine (6-MMP). Preliminary studies have suggested that the red blood cell concentratio...

Treatment of autoimmune hemolytic anemia in children with azathioprine (imuran).

velopment of azathioprine ( Imuran ) , a derivative of 6-mercaptopurine. The efficacy of purine antagonists has been proved in clinical trials by suppression of homograft rejection and autoimmune diseases, particularly autoimmune hemolytic anemia/LlT Several publications deal with the application of this treatment to adults, ’4’1 #{176}’17 but to the best of our knowledge this is the first comm...

Therapeutic effects of azathioprine in combination with low-dose prednisolone in patients with intractable autoimmune hepatitis type 1.

This study evaluated the effects of azathioprine in combination with low-dose prednisolone in the management of patients with intractable autoimmune hepatitis. Thirteen patients with intractable autoimmune hepatitis who had an incomplete or arrested response to conventional prednisolone therapy, or who relapsed during prednisolone maintenance therapy were additionally administered 50 or 100 mg/...

Author’s response to reviews Title: Relationship between Azathioprine Metabolites and Therapeutic Efficacy in Chinese Patients with Neuromyelitis Optica Spectrum Disorders Authors: